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6565 West Loop South 530, Bellaire, TX 77401, US

ONE‑D: Optimized Neuroplastogen‑Enhanced Treatment Regimen (One Day)

Fast. Focused. Life‑changing.

ONE‑D is a breakthrough single‑day TMS protocol that delivers a full therapeutic course in just one visit. Built for people who need effective relief without the weeks of traditional sessions, it blends high‑dose TMS with smart neuroplasticity support.

How It Works

20 iTBS sessions (intermittent Theta Burst Stimulation), each ~3 minutes
Spaced every 30 minutes over ~9.5 hours—a full course in a day (Biological Psychiatry Journal, Neurocare Group)
Pre-treatment medications taken ~60 minutes before:
- D‑cycloserine (125 mg) — enhances neuroplasticity
- Lisdexamfetamine (Vyvanse, 20 mg) — supports focus and prefrontal engagement (Neurocare Group, Biological Psychiatry Journal, Patient Care Online)
Treatments target the left dorsolateral prefrontal cortex (DLPFC) using reliable scalp-based positioning (no fMRI needed) (Biological Psychiatry Journal)
Careful monitoring in a supportive, structured clinical setting ensures both safety and comfort.

What the Evidence Shows

Clinical Outcomes (Retrospective Case Series, 32 Patients)

Week 6 post-treatment

Week 12 follow-up

Outcomes remained strong across measures (e.g., HDRS‑17: ~92.6% response, ~77.8% remission) (breakthrupsych.com, stimulatingbrains.org)

Safety & Tolerability

All participants completed the session with no serious adverse events; mild scalp discomfort reported (mean 5.8/10) (stimulatingbrains.org)

Additional Studies & Real‑World Reports

These figures significantly outperform standard TMS remission rates (~30–35%) and condensed accelerated protocols (Patient Care Online).

Why ONE‑D?

One single treatment day—no need for multiple clinic visits
Rapid, durable relief—benefits emerge over weeks and persist, with many still well at 12‑week check-in (Neurocare Group, Patient Care Online)
High efficacy, especially for treatment-resistant depression
Low side-effect profile, well-tolerated
Convenience for busy lives—perfect for professionals, travelers, or anyone with limited availability

Is ONE‑D Right for You?

Consider ONE‑D if you:

Have struggled with multiple antidepressants
Want a science-backed, efficient option with strong outcomes
Prefer minimal clinic visits and faster progress

Note: The protocol uses off-label medications (D‑cycloserine and Vyvanse) and, in many clinics, is self‑pay only—typically not covered by insurance (breakthrupsych.com, clearpathpsychiatry.com).

Ready for a One‑Day Transformation?

If this fast-track approach to wellness speaks to you, let’s talk. Schedule a consultation or connect with us today to explore ONE‑D TMS and take control—without trading months of your life.

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